Highlights the early risks of intracranial hemorrhage and myocardial rupture associated with thrombolytic therapy for acute myocardial infarction and proposes potential preventive strategies.
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Merits caution for early intracranial hemorrhage and rupture with thrombolysis; proposed preventive strategies remain hypothesis-generating.
By restoring coronary flow, thrombolytic therapy for acute myocardial infarction diminishes infarct size and left ventricular dysfunction, resulting in better early and late outcome. Thrombolytic therapy has, however, an inherent early risk, that of intracranial hemorrhage and, possibly, myocardial rupture. An effective strategy in reducing this early risk has not so far been available, but lowering of blood pressure and reduction of myocardial contractility may be candidates for further study aiming to fight these often fatal complications of a life-saving therapy for acute myocardial infarction.
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F.W.A. Verheugt (1998) studied this question.
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