January 1, 1996Journal of Hypertension

Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives

View Full Paper

Ask AI

Bookmark

Why the study?

Does acute modulation of insulin levels with somatostatin and insulin infusion alter arterial pressure and forearm vascular resistance in obese, insulin-resistant hypertensive men?

Population

11 obese, insulin-resistant, hypertensive men, with control groups of 6 obese hypertensives and 6 young…

Comparison

Somatostatin infusion for 2 hours followed by… vs Time/vehicle control in 6 obese hypertensives…

Follow-up

4 hours

Authors

SRSoffia Gudbj rnsdottirUniversity of Iowa MEMikael ElamSahlgrenska University Hospital JSJohan SellgrenUniversity of Gothenburg

Discussion

Member takes

Implication

Insulin may exert vasoconstrictive effects in obese hypertensive men; hypothesis-generating and should not change practice.

Structured PICO

Does acute modulation of insulin levels with somatostatin and insulin infusion alter arterial pressure and forearm vascular resistance in obese, insulin-resistant hypertensive men?

Population

11 obese (body mass index 36 +/- 4 kg/m2), insulin-resistant, hypertensive men (systolic/diastolic blood pressures 153 +/- 6/94 +/- 2 mmHg, aged 51 +/- 7 years, fasting insulin level 17 +/- 8 mU/l), with control groups of 6 obese hypertensives and 6 young normotensives.

Intervention

Somatostatin infusion for 2 hours followed by somatostatin plus insulin infusion for 2 hours (hyperinsulinemic or euglycemic clamp).

Comparator

Time/vehicle control in 6 obese hypertensives, and somatostatin infusion in 6 young normotensives.

Outcome

Arterial pressure, forearm blood flow, and forearm vascular resistance.surrogate

Insulin causes forearm vasoconstriction and increases arterial pressure in obese, insulin-resistant hypertensive humans, highlighting a direct vascular effect of insulin in this population.

Cite This Study

rnsdottir et al. (1996) studied this question.

synapsesocial.com/papers/6a7a992c1ba4614d7ff3f8b9 https://doi.org/10.1097/00004872-199601000-00012

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider