October 1, 1992American Journal of Hypertension

Insulin Resistance, Hyperinsulinemia, and Dyslipidemia in Nonobese Individuals With a Family History of Hypertension

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Why the study?

Does a family history of hypertension associate with insulin resistance, hyperinsulinemia, and dyslipidemia in nonobese normotensive individuals?

Population

76 nonobese normal volunteers, consisting of 38 with and 38 without a family history of hypertension. Groups…

Comparison

Family history of hypertension vs No family history of hypertension

Design

Cross-sectional

Authors

FFFrancesco FacchiniPolytechnic University of Bari YCY.-D Ida ChenPalo Alto University CCCynthia ClinkingbeardJoslin Diabetes Center

Discussion

Member takes

Implication

Supports preclinical metabolic changes in hypertension families; leaves open whether screening or intervention alters outcomes.

Structured PICO

Does a family history of hypertension associate with insulin resistance, hyperinsulinemia, and dyslipidemia in nonobese normotensive individuals?

Population

76 nonobese normal volunteers (normotensive), consisting of 38 with and 38 without a family history of hypertension. Groups were comparable in age, gender distribution, and degree of obesity.

Intervention

Family history of hypertension

Comparator

No family history of hypertension

Outcome

Glucose, insulin, and lipid metabolism parameters (including glucose-stimulated insulin concentrations, steady state plasma glucose concentration, VLDL triglyceride, VLDL cholesterol, and total to HDL cholesterol ratio)surrogate

Normotensive individuals with a family history of hypertension exhibit insulin resistance, hyperinsulinemia, and dyslipidemia, suggesting early metabolic abnormalities precede the onset of clinical hypertension.

Cite This Study

Facchini et al. (1992) studied this question.

synapsesocial.com/papers/6a7a992c1ba4614d7ff3f8bc https://doi.org/10.1093/ajh/5.10.694

Topics

Hypertension management

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