Why the study?
Pre-dialysis SBP and peridialytic SBP change are linked to morbidity and mortality in hemodialysis patients, but the nature of their interaction is not well understood.
How do pre-dialysis systolic blood pressure and peridialytic SBP change interact to affect all-cause mortality in chronic hemodialysis patients?
Population
172 199 HD patients treated in US Fresenius Medical Care facilities
Comparison
Pre-HD SBP and peridialytic SBP change levels and interactions
Design
Observational cohort study
Follow-up
Median 25.0 months
Authors
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Peridialytic SBP rise signals higher mortality only with elevated pre-HD SBP in HD; leaves open whether modifying intradialytic trajectories improves outcomes.
How do pre-dialysis systolic blood pressure and peridialytic SBP change interact to affect all-cause mortality in chronic hemodialysis patients?
The association of pre-dialysis and peridialytic SBP change with mortality in hemodialysis patients is complex and requires joint interpretation, as a peridialytic SBP rise is harmful with high pre-HD SBP but protective with low pre-HD SBP.
Zhang et al. (2019) studied this question.
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