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January 1, 1995Thrombosis and Haemostasis

Factors that Contribute to Spontaneous Platelet Aggregation and Streptokinase-Induced Aggregation in Whole Blood

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Population

Citrated whole blood obtained from healthy volunteers

Design

Preclinical

Authors

RARuth ArmstrongCambridge University Hospitals NHS Foundation TrustJMJane MayUniversity of NottinghamWLWolfgang LöscheUniversity of Erfurt

Discussion

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Implication

May guide adjunctive strategies to limit streptokinase-induced aggregation; leaves open in vivo validation and clinical translation.

Structured PICO

P
Population
Citrated whole blood obtained from healthy volunteers
I
Intervention
In vitro addition of various inhibitors and antagonists (apyrase, FPL 66096, chlorpromazine, sulotroban, iloprost, SIN-1, EDTA, RGDS, MgCl2)
O
Outcome
Platelet aggregation (spontaneous and streptokinase-induced) measured using a platelet counting techniquesurrogate

In vitro whole blood studies demonstrate that ADP, divalent cations, and RGD-containing adhesive proteins mediate both spontaneous and streptokinase-induced platelet aggregation.

Cite This Study

Armstrong et al. (1995) studied this question.

synapsesocial.com/papers/6a7aaa9b9092edbae3f3b52chttps://doi.org/10.1055/s-0038-1653768

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Original Article: Streptokinase Modifies in Vitro Platelet Aggregation by Two Mechanisms: Reduced Aggregation due to Fibrinogenolysis and Enhanced Aggregation via an Immunological Reaction1995 · 7 citations
  2. 2Plasmin-Induced Platelet Aggregation and Platelet Release Reaction. EFFECTS ON HEMOSTASIS1973 · 129 citations
  3. 3Spontaneous Platelet Aggregation in Cerebrovascular Disease II1979 · 53 citations
  4. 4Streptokinase, but not tissue plasminogen activator, attenuates platelet aggregation in patients with acute myocardial infarction1993 · 9 citations
  5. 5Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells.1993 · 45 citations