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October 1, 1993Circulation

Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells.

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Why the study?

Does streptokinase induce the release of platelet-activating factor in patients with acute myocardial infarction?

Population

25 patients with acute myocardial infarction and cultured human umbilical cord vein-derived endothelial cells.

Comparison

Intravenous infusion of streptokinase in… vs Untreated patients with comparable infarct (n=11).

Design

Cohort

Follow-up

120 to 180 minutes

Authors

GMGiuseppe MontrucchioUniversity of ParmaSBSerena BergeroneAzienda Ospedaliera Citta' della Salute e della Scienza di TorinoFBFederico BussolinoCandiolo Cancer Institute

Discussion

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Implication

SK-induced PAF may attenuate thrombolytic efficacy in AMI; hypothesis-generating for adjunctive inhibition in future trials.

Structured PICO

Does streptokinase induce the release of platelet-activating factor in patients with acute myocardial infarction?

P
Population
25 patients with acute myocardial infarction (n=14 treated with streptokinase, n=11 untreated) and cultured human umbilical cord vein-derived endothelial cells (ECs).
I
Intervention
Intravenous infusion of streptokinase (SK) in patients; SK or plasmin stimulation in cultured ECs.
C
Comparator
Untreated patients with comparable infarct (n=11).
O
Outcome
Presence and quantification of platelet-activating factor (PAF) in blood samples and synthesis by cultured ECs.surrogate

Streptokinase induces the release of platelet-activating factor in patients with acute myocardial infarction, which may promote platelet activation and limit the efficacy of thrombolytic therapy.

Cite This Study

Montrucchio et al. (1993) studied this question.

synapsesocial.com/papers/6a853dc90b777c8ef096485dhttps://doi.org/10.1161/01.cir.88.4.1476
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity1988 · 13 citations
  2. 2Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.1986 · 125 citations
  3. 3Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin1989 · 21 citations
  4. 4Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released <i>in Vivo</i> during IgE Anaphylaxis with PAF Released <i>in Vitro</i> from IgE Sensitized Basophils1979 · 449 citations
  5. 5Platelets and Thrombolytic Therapy1990 · 485 citations