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January 1, 1995Platelets

Original Article: Streptokinase Modifies in Vitro Platelet Aggregation by Two Mechanisms: Reduced Aggregation due to Fibrinogenolysis and Enhanced Aggregation via an Immunological Reaction

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Population

Plasma and platelets from healthy volunteers and patients previously treated with streptokinase for acute…

Design

Preclinical

Authors

MAM. AbdelouahedUniversity Hospital of OranIEIsmaı̈l ElalamyHôpital américain de parisJLJ. LebraziHôtel-Dieu de Paris

Discussion

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Implication

Animal data implicate Fc-FcγRII interaction in SK platelet effects; hypothesis-generating for human relevance and interventions.

Structured PICO

P
Population
Plasma and platelets from healthy volunteers and patients previously treated with streptokinase for acute myocardial infarction
I
Intervention
Streptokinase (SK) exposure in vitro
O
Outcome
Mechanisms of SK-induced and SK-enhanced ADP-induced platelet aggregationsurrogate

Streptokinase modifies platelet aggregation through two distinct mechanisms: inhibition via fibrinogen degradation and enhancement via an immunological reaction involving anti-SK antibodies and platelet FcyRII receptors.

Cite This Study

Abdelouahed et al. (1995) studied this question.

synapsesocial.com/papers/6a8663eaae12ed54832fe2cahttps://doi.org/10.3109/09537109509078465
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasmin-Induced Platelet Aggregation and Platelet Release Reaction. EFFECTS ON HEMOSTASIS1973 · 129 citations
  2. 2Immunoglobulin response to intravenous streptokinase in acute myocardial infarction.1991 · 72 citations
  3. 3Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.1989 · 126 citations
  4. 4PL2‐49, a monoclonal antibody against glycoprotein IIb which is a platelet activator1989 · 47 citations
  5. 5Platelet activation by CD9 monoclonal antibodies is mediated by the FCγII receptor1990 · 137 citations