June 1, 1983The Journal of PhysiologyOpen Access

The influence of pH on the healing‐over of mammalian cardiac muscle.

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Population

Trabeculae from the right ventricle of guinea-pigs and Purkinje fibres from dogs

Design

Preclinical

Authors

WMWalmor C. De MelloNational Institutes of Health

Discussion

Member takes

Implication

Extreme acidosis may enable proton-mediated healing-over in injured myocardium; hypothesis-generating for Ca2+-independent repair and leaves clinical relevance open.

Structured PICO

Population

Trabeculae from the right ventricle of guinea-pigs and Purkinje fibres from dogs

Intervention

Ca2+-free bathing solution at various pH levels (6.5, 5.5, 5.0, 4.0)

Outcome

Healing-over process measured by resting potential and input resistance close to a site of damagesurrogate

Protons can substitute for calcium in mediating the healing-over process of damaged cardiac muscle under extreme low pH conditions.

Cite This Study

Walmor C. De Mello (1983) studied this question.

synapsesocial.com/papers/6a7aabebf48aafa9d7f38f32 https://doi.org/10.1113/jphysiol.1983.sp014717

View Full Paper

Ask AI

Bookmark

Implication

Extreme acidosis may enable proton-mediated healing-over in injured myocardium; hypothesis-generating for Ca2+-independent repair and leaves clinical relevance open.

The influence of pH on the healing‐over of mammalian cardiac muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The influence of pH on the healing‐over of mammalian cardiac muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider