Why the study?
MicroRNAs are under investigation as cardiovascular biomarkers, but whether specific cardio-miRNAs are overexpressed in heart samples from subjects deceased from acute myocardial infarction or sudden cardiac death, and can differentiate between them, is unknown.
Can specific cardio-miRNAs (miR-1, miR-499, miR-208) differentiate between sudden cardiac death, acute myocardial infarction, and non-cardiac death in post-mortem heart samples?
Comparison
AMI vs SCD vs traumatic death controls
Design
Post-mortem case-control study
Authors
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Post-mortem miRNA profiling may distinguish AMI from SCD; leaves open clinical biomarker utility pending validation.
Can specific cardio-miRNAs (miR-1, miR-499, miR-208) differentiate between sudden cardiac death, acute myocardial infarction, and non-cardiac death in post-mortem heart samples?
Specific cardio-miRNAs (miR-1, miR-499, and miR-208) can serve as accurate post-mortem biomarkers to differentiate between acute myocardial infarction and sudden cardiac death.
Pinchi et al. (2019) studied this question.
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