Why the study?
Does neuroleptic treatment with haloperidol or clozapine affect cardiovascular autonomic reactivity in schizophrenic patients compared to healthy volunteers?
Does neuroleptic treatment with haloperidol or clozapine affect cardiovascular autonomic reactivity in schizophrenic patients compared to healthy volunteers?
Clozapine treatment significantly impairs cardiovascular autonomic reactivity in schizophrenic patients, and greater heart rate variability may predict positive short-term psychiatric treatment response.
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Clozapine may impair autonomic reactivity in schizophrenia; leaves open need for monitoring or outcome impact.
Agelink et al. (1998) studied this question.
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