Key result
A circulating neutrophil count ≥ 9.14 × 10^9/L was independently predictive of no-reflow in patients with acute STEMI following primary PCI (OR 4.474; 95% CI 1.610-12.433; P=0.004).
Why the study?
Does an elevated circulating neutrophil count predict angiographic no-reflow in patients with acute STEMI following successful primary PCI?
Population
361 patients diagnosed with acute ST-segment elevation myocardial infarction between 2011 and 2015 who…
Comparison
Circulating neutrophil count ≥ 9.14 × 10^9/L vs Circulating neutrophil count < 9.14 × 10^9/L
Design
Cohort
Authors
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Elevated neutrophils may aid no-reflow risk stratification in STEMI post-PCI; hypothesis-generating for targeted interventions.
Cohort (n=361)
Does an elevated circulating neutrophil count predict angiographic no-reflow in patients with acute STEMI following successful primary PCI?
Odds Ratio: 4.474 (95% CI 1.61–12.433)
p-value: p=0.004
An elevated circulating neutrophil count (≥ 9.14 × 10^9/L) is a strong independent predictor of angiographic no-reflow in patients with acute STEMI undergoing primary PCI.
Tian et al. (2017) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=361). Neutrophil count ≥ 9.14 × 10^9/L vs. Neutrophil count < 9.14 × 10^9/L was evaluated on Angiographic no-reflow (post-PCI TIMI flow grade ≤ 2 without mechanical obstruction) (OR 4.474, 95% CI 1.610-12.433, p=0.004). A circulating neutrophil count ≥ 9.14 × 10^9/L was independently predictive of no-reflow in patients with acute STEMI following primary PCI (OR 4.474; 95% CI 1.610-12.433; P=0.004).
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