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November 9, 2009CirculationOpen Access

Left Atrial Appendage Occlusion Eliminates the Need for Warfarin

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Key result

Left atrial appendage occlusion is discussed as a strategy to eliminate the need for warfarin in patients with atrial fibrillation to prevent stroke, which has an incidence of 780,000 cases yearly.

Authors

David R. Holmes
David R. HolmesInterventional / Structural Cardiology
RSRobert S. SchwartzGeneral Cardiology

Discussion

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Overview

LAAO discussion for warfarin avoidance in AF is hypothesis-generating; leaves open efficacy confirmation versus anticoagulation in randomized trials.

PICO

P
Population
Atrial fibrillation and stroke
I
Intervention / Comparator
Left Atrial Appendage Occlusion vs Warfarin

Cite This Study

Holmes et al. (2009) conducted an editorial in Atrial fibrillation and stroke. Left Atrial Appendage Occlusion vs. Warfarin was evaluated. Left atrial appendage occlusion is discussed as a strategy to eliminate the need for warfarin in patients with atrial fibrillation to prevent stroke, which has an incidence of 780,000 cases yearly.

synapsesocial.com/papers/6a7b60f1e357fbdac589d952https://doi.org/10.1161/circulationaha.108.844761

Topics

Left atrial appendage closureAtrial fibrillationAnticoagulation in AFPersistent AF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation1990 · 1,539 citations
  2. 2Optimal Oral Anticoagulant Therapy in Patients with Nonrheumatic Atrial Fibrillation and Recent Cerebral Ischemia1995 · 426 citations
  3. 3Age and the Risk of Warfarin‐Associated Hemorrhage: The Anticoagulation and Risk Factors In Atrial Fibrillation Study2006 · 251 citations
  4. 4Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation2007 · 1,065 citations
  5. 5Benefit of Oral Anticoagulant Over Antiplatelet Therapy in Atrial Fibrillation Depends on the Quality of International Normalized Ratio Control Achieved by Centers and Countries as Measured by Time in Therapeutic Range2008 · 875 citations