Why the study?
Does captopril modify heart failure-associated gene expression in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats without heart failure and SHR with heart failure.
Comparison
Captopril 2 g/L in drinking water vs Age-matched normotensive Wistar-Kyoto rats, and…
Design
Preclinical
Authors
Loading...
Supports mechanistic research on ACE inhibitors in hypertensive HF; leaves open human translation.
Does captopril modify heart failure-associated gene expression in spontaneously hypertensive rats?
Captopril prevents and partially reverses heart failure-associated changes in myocardial gene expression in a hypertensive rat model.
Brooks et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: