Why the study?
Does ACE inhibition reduce intracellular Na+ activity in rabbit cardiac myocytes?
Does ACE inhibition reduce intracellular Na+ activity in rabbit cardiac myocytes?
ACE inhibitors reduce intracellular Na+ activity and increase Na(+)-K+ pump activity in rabbit cardiac myocytes, providing a potential mechanism for their ability to reduce cardiac mass.
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ACE inhibition effects on myocyte Na+ in rabbits warrant clinical caution; leaves open mechanistic contribution to reduced cardiac mass in humans.
Hool et al. (1995) studied this question.
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