Key result
Moxonidine reduced the tachycardic response to emotional stress in normotensive rats, an effect that was abolished by prior administration of the imidazoline receptor blocker efaroxan.
Why the study?
The study was conducted to evaluate the vegetotropic and emotional-behavioral effects of the imidazoline receptor agonist moxonidine.
Moxonidine reduces the tachycardic response to emotional stress in normotensive rats via imidazoline receptors, though its baseline hemodynamic effects are minimal compared to hypertensive models.
Answers are grounded in this paper and cite their sources.
Animal findings on moxonidine's autonomic effects require human validation; leaves open clinical translation.
The purpose of this work was to study the vegetotropic and emotional-behavioral effects of the imidazoline receptor agonist moxonidine. Materials and methods . In awake males of the Wistar line, the effect of moxonidine in various doses (without and with the preliminary introduction of the predominant blocker of the imidazoline receptors of efaroxan) on hemodynamic parameters, heart rate variability (HRV), cardiovascular response to stress and on the behavior in the “open field” test was studied. Results . It was shown that moxonidine in the studied doses does not significantly affect the hemodynamic parameters, the components of the HRV spectrum and the locomotor activity of animals, however, it reduces the tachycardic response to the call. The last effect of moxonidine is removed by the preliminary administration of efaroxane. Conclusion . Based on the results of the study and literature data, it can be assumed that different types of receptors are involved in reducing the cardiovascular response to stress and in the sedative effect of drugs of the imidazoline group. In the first case, the effect is due to the activation of I1 receptors, in the second — α2-adrenergic receptors. Also, the results of the experiments allow us to conclude that in normotensive rats, the functional activity of imidazoline receptors is reduced in comparison with hypertensive rats. Perhaps this circumstance explains the low efficacy of moxonidine in Wistar rats.
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Цырлин et al. (2020) studied Normotensive (n=40). Moxonidine vs. Saline or baseline was evaluated on Change in intersystolic interval (tachycardic response) to emotional stress (p=<0.01). Moxonidine reduced the tachycardic response to emotional stress in normotensive rats, an effect that was abolished by prior administration of the imidazoline receptor blocker efaroxan.
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