Key result
Moxonidine at low doses (0.04-0.36 mg/kg) showed weak parasympatholytic effects, while high doses (1.08-3.24 mg/kg) were strongly parasympathomimetic in rats.
Why the study?
Does moxonidine modulate cardiac parasympathetic activity in rats?
Does moxonidine modulate cardiac parasympathetic activity in rats?
Moxonidine demonstrates a biphasic dose-dependent modulation of cardiac parasympathetic activity, acting as a weak parasympatholytic at low doses and a strong parasympathomimetic at high doses.
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Hypothesis-generating for moxonidine's dose-dependent autonomic effects in rats; human studies required before clinical relevance can be assessed.
Marian Turčáni (2008) studied this question. Moxonidine was evaluated on Heart rate and blood pressure variability and baroreflex sensitivity. Moxonidine at low doses (0.04-0.36 mg/kg) showed weak parasympatholytic effects, while high doses (1.08-3.24 mg/kg) were strongly parasympathomimetic in rats.
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