Key result
In female mRen(2).Lewis rats, a high-salt diet led to a 180-fold increase in urinary angiotensinogen excretion (1.8 vs. 0.01 µg/kg/day, p<0.01) and increased blood pressure.
Effect estimate: 180-fold increase
Absolute Event Rate: 1.8% vs 0.01%
p-value: p=<0.01
In the mRen2 hypertension model, increased urinary angiotensinogen with estrogen depletion or high salt likely reflects glomerular damage and filtration of circulating protein rather than increased renal synthesis.
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Suggests urinary angiotensinogen marks glomerular injury rather than renal synthesis in this model; hypothesis-generating for human salt-sensitive hypertension.
Cohen et al. (2010) studied Hypertension (n=36). High-salt diet vs. Normal salt diet (1% NaCl) was evaluated on Urinary angiotensinogen (uAGT) excretion in females (µg/kg/day) (180-fold increase, p=<0.01). In female mRen(2).Lewis rats, a high-salt diet led to a 180-fold increase in urinary angiotensinogen excretion (1.8 vs. 0.01 µg/kg/day, p<0.01) and increased blood pressure.
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