Why the study?
Does initial pulse pressure predict long-term decline in renal function in essential hypertensive patients?
Population
375 essential hypertensive patients initially untreated, with normal renal function and without proteinuria…
Design
Cohort
Follow-up
mean 14 years
Authors
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May flag higher renal risk in new hypertensives; extends observational links to arterial stiffness but leaves open need for trials.
Does initial pulse pressure predict long-term decline in renal function in essential hypertensive patients?
Initial pulse pressure is an independent predictor of long-term renal function decline in essential hypertensive patients, suggesting a role for arterial stiffness in glomerular barotrauma.
Gosse et al. (2009) studied this question.
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