August 6, 2007Journal of Hypertension
Pulse pressure is an independent determinant of renal function decline during treatment of essential hypertension
Why the study?
Does baseline pulse pressure predict renal function decline in patients with essential hypertension undergoing antihypertensive treatment?
Population
132 never-treated patients with essential hypertension at baseline
Design
Cohort
Follow-up
median 5.8 years
Authors
Discussion
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Member takes
Implication
May aid renal risk stratification in treated hypertension; hypothesis-generating and requires prospective confirmation before guiding therapy.
Structured PICO
Does baseline pulse pressure predict renal function decline in patients with essential hypertension undergoing antihypertensive treatment?
P
Population
132 never-treated patients with essential hypertension at baseline
I
Intervention
Antihypertensive treatment (64% received angiotensin-converting enzyme inhibitors)
O
Outcome
Yearly change in glomerular filtration rate (GFR) and effective renal plasma flow, estimated by urinary clearances of isotopic markerssurrogate
Baseline pulse pressure, a marker of arterial stiffness, independently predicts accelerated renal function decline in patients treated for essential hypertension.
Cite This Study
Fesler et al. (2007) studied this question.