Key result
Reflected wave pressure, but not forward wave pressure, was independently associated with end-organ damage such as pulse wave velocity (partial r=0.28, P<0.0001) and carotid IMT.
Why the study?
Are brachial blood pressure-independent relations between aortic pressure and cardiovascular damage better explained by reflected or forward wave pressure effects in an African community?
Cross-Sectional (n=1,174)
Are brachial blood pressure-independent relations between aortic pressure and cardiovascular damage better explained by reflected or forward wave pressure effects in an African community?
p-value: p=<0.0001
In communities of African ancestry, brachial BP-independent relations between aortic pressure and end-organ changes are largely driven by reflected rather than forward wave pressures.
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Pb may refine central BP risk assessment beyond brachial measures in African ancestry groups; leaves open whether targeting reflection improves outcomes.
Sibiya et al. (2015) conducted a cross-sectional in Cardiovascular damage (n=1,174). Reflected (backward) wave pressure (Pb) vs. Forward wave pressure (Pf) was evaluated on End-organ measures including LVMI, PWV, IMT, E/A, and eGFR (p=<0.0001). Reflected wave pressure, but not forward wave pressure, was independently associated with end-organ damage such as pulse wave velocity (partial r=0.28, P<0.0001) and carotid IMT.
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