Key result
P2-derived central pulse pressure was independently associated with left ventricular mass (partial r=0.18, P<0.0001) and carotid intima-media thickness (partial r=0.40, P<0.0001).
Why the study?
Is P2-derived central pulse pressure associated with target organ changes independently of brachial blood pressure?
Population
678 individuals assessed for left ventricular mass and 462 assessed for carotid intima-media thickness
Comparison
Measurement of central aortic blood pressure… vs Generalized transfer function-derived central…
Design
Cross-sectional
Authors
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Hypothesis-generating for P2 as a simple central PP marker; prospective studies needed before clinical use.
Observational (n=678)
Is P2-derived central pulse pressure associated with target organ changes independently of brachial blood pressure?
Effect estimate: partial r=0.18 (LV mass) and 0.40 (IMT)
p-value: p=<0.0001
Central pulse pressure derived from the late systolic shoulder of the radial waveform (P2) is associated with target organ damage independently of brachial blood pressure, offering a simpler alternative to generalized transfer functions.
Norton et al. (2012) reported an observational. P2-derived central pulse pressure vs. nurse-derived brachial pulse pressure was evaluated on Left ventricular mass indexed for height(1.7) and carotid intima-media thickness (IMT) (partial r=0.18 (LV mass) and 0.40 (IMT), p=<0.0001). P2-derived central pulse pressure was independently associated with left ventricular mass (partial r=0.18, P<0.0001) and carotid intima-media thickness (partial r=0.40, P<0.0001).
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