Key result
EndoPAT measurement did not detect decreased endothelial function in renally impaired (2.9) or diabetic patients (1.8) compared to healthy volunteers (1.8, P>0.05).
Why the study?
Is the EndoPAT a feasible and discriminating tool to assess endothelial function and its acute changes in different populations?
Population
Renally impaired patients, type 2 diabetic patients, and healthy volunteers
Comparison
EndoPAT measurement to assess endothelial… vs Healthy volunteers and baseline measurements
Authors
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EndoPAT may lack sensitivity for endothelial dysfunction in renally impaired or diabetic patients; leaves open its utility and requires validation before adoption.
Observational
Is the EndoPAT a feasible and discriminating tool to assess endothelial function and its acute changes in different populations?
Absolute Event Rate: 2.9% vs 1.8%
p-value: p=>0.05
The EndoPAT device may not be suitable for assessing acute changes in endothelial function in early-phase clinical pharmacology studies, as it failed to discriminate between healthy and diseased populations or detect effects of robust interventions.
Moerland et al. (2012) conducted an observational in Endothelial dysfunction. EndoPAT measurement vs. Healthy volunteers was evaluated on Endothelial function (p=>0.05). EndoPAT measurement did not detect decreased endothelial function in renally impaired (2.9) or diabetic patients (1.8) compared to healthy volunteers (1.8, P>0.05).
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