Determinants of Vascular Smooth Muscle Cell Apoptosis After Balloon Angioplasty Injury
Population
rabbit carotid artery model of balloon-catheter distention injury
Design
Preclinical
Follow-up
up to 90 minutes
Authors
Discussion
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Member takes
Implication
Antioxidants attenuate early apoptosis after experimental vascular injury; leaves open whether redox modulation affects human restenosis.
Structured PICO
P
Population
rabbit carotid artery model of balloon-catheter distention injury
I
Intervention
Administration of antioxidants (N-acetyl cysteine or pyrrolidine dithiocarbamate) following balloon angioplasty injury
O
Outcome
Vascular smooth muscle cell apoptosis and medial cell losssurrogate
Acute apoptotic cell death after vascular injury is regulated by cellular redox state and antiapoptotic gene expression, which may be an important determinant of vascular remodeling and restenosis.
Cite This Study
Pollman et al. (1999) studied this question.