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January 1, 1992Journal of General Virology

Heterogeneous expression of the non-structural protein p80/p125 in cells infected with different pestiviruses

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Population

Cells infected with cytopathic and non-cytopathic bovine viral diarrhoea virus strains and isolates, and…

Design

Preclinical

Authors

IGI. Greiser‐WilkeKDKurt E.J. DittmarBLB. Ließ

Discussion

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Overview

Suggests recombination drives cpBVD ns p125 heterogeneity; hypothesis-generating for pathogenesis with no immediate clinical implications.

Structured PICO

P
Population
Cells infected with cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhoea (BVD) virus strains and isolates, and with hog cholera (HC) virus strains
I
Intervention
Radioimmunoprecipitations with the pestivirus-specific monoclonal antibody (MAb) BVD/C16
O
Outcome
Expression and size heterogeneity of the non-structural (ns) protein p80/p125

The heterogeneous expression of ns p125 in cpBVD virus populations may result from multiple recombination events in the genomes of ncpBVD viruses.

Cite This Study

Greiser‐Wilke et al. (1992) studied this question.

synapsesocial.com/papers/6a7c00461f8f1eb7b8ed4e37https://doi.org/10.1099/0022-1317-73-1-47
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent Advances in Pestivirus Research1989 · 187 citations
  2. 2Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus1985 · 259 citations