What question did this study set out to answer?

To evaluate a calibration procedure using citrated fresh plasma to determine the International Sensitivity Index across two whole blood point-of-care prothrombin time monitors.

January 1, 2002Thrombosis and Haemostasis

European Concerted Action on Anticoagulation

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Why the study?

Does citrated fresh plasma calibration provide reliable INR compared to whole blood calibration in point-of-care prothrombin time monitors?

Population

Whole blood and fresh plasma samples for prothrombin time monitoring

Comparison

Citrated fresh plasma calibration for… vs Whole blood sample calibration

Design

Other

Authors

ABA.M.H.P. van den BesselaarLeiden University Medical Center ATA. TripodiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico CSCaroline ShiachUniversity of Liverpool

Discussion

Member takes

Implication

Plasma calibration may enable reliable CoaguChek Mini whole blood INR; hypothesis-generating for other monitors and needs clinical validation.

Key Points

To evaluate a calibration procedure using citrated fresh plasma to determine the International Sensitivity Index across two whole blood point-of-care prothrombin time monitors.
Conducted a multicentre calibration study evaluating two point-of-care prothrombin time systems: CoaguChek Mini and TAS PT-NC.
Calibrated International Sensitivity Index (ISI) values using citrated fresh plasma and compared them to whole blood calibrations against reference International Normalised Ratio (INR) target samples.
Both point-of-care systems produced higher ISI values when calibrated with whole blood than when calibrated with fresh plasma.
INR determinations derived from both whole blood and fresh plasma demonstrated strong agreement with the reference INR values on both systems.
The CoaguChek Mini successfully derived reliable whole blood INR results using plasma calibration ISI, whereas the TAS PT-NC system could not interchange these calibrations.

Structured PICO

Does citrated fresh plasma calibration provide reliable INR compared to whole blood calibration in point-of-care prothrombin time monitors?

Population

Whole blood and fresh plasma samples for prothrombin time monitoring

Intervention

Citrated fresh plasma calibration for International Sensitivity Index (ISI) of CoaguChek Mini and TAS PT-NC point-of-care test systems

Comparator

Whole blood sample calibration

Outcome

Agreement between monitor system International Normalised Ratio (INR) and reference INR of target samplessurrogate

Reliable INR can be obtained with both whole blood and plasma samples on CoaguChek Mini and TAS PT-NC systems based on their respective ISI, though cross-sample type calibration is only viable for CoaguChek Mini.

Cite This Study

Besselaar et al. (2002) studied this question.

synapsesocial.com/papers/6a7c062bc2a640f0bcdf8ec3 https://doi.org/10.1055/s-0037-1613097

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Implication

Plasma calibration may enable reliable CoaguChek Mini whole blood INR; hypothesis-generating for other monitors and needs clinical validation.

European Concerted Action on Anticoagulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

European Concerted Action on Anticoagulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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