October 1, 2002Clinical ChemistryOpen Access

European Concerted Action on Anticoagulation. Evaluation of a Method for International Sensitivity Index Calibration of Two Point-of-Care Prothrombin Time (PT) Monitoring Systems (CoaguChek Mini and TAS PT-NC) with Fresh Plasmas Based on Whole-Blood Equivalent PT

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Why the study?

Does a linear correction method resolve the discrepancy between whole-blood and fresh plasma ISI calibrations for POCT PT monitors?

Population

Whole blood and fresh plasma samples used for calibration of point-of-care testing prothrombin time monitors

Comparison

Linear correction method to adjust the… vs Uncorrected ISI difference

Design

Other

Authors

LPL. PollerCross-Cutting Cardiology MKMichelle KeownUniversity of Edinburgh NCNikhil ChauhanChandigarh University

Discussion

Member takes

Implication

Linear correction may simplify POCT PT monitor calibration; leaves open prospective validation before clinical adoption.

Structured PICO

Does a linear correction method resolve the discrepancy between whole-blood and fresh plasma ISI calibrations for POCT PT monitors?

Population

Whole blood and fresh plasma samples used for calibration of point-of-care testing (POCT) prothrombin time (PT) monitors

Intervention

Linear correction method to adjust the difference between whole-blood and plasma International Sensitivity Index (ISI)

Comparator

Uncorrected ISI difference

Outcome

Difference between whole-blood and plasma ISIsurrogate

A linear correction method resolves the discrepancy between whole-blood and fresh plasma ISI calibrations for TAS PT-NC test cards, simplifying POCT PT monitor calibration.

Cite This Study

Poller et al. (2002) studied this question.

synapsesocial.com/papers/6a7c062bc2a640f0bcdf8ebf https://doi.org/10.1093/clinchem/48.10.1672

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European Concerted Action on Anticoagulation. Evaluation of a Method for International Sensitivity Index Calibration of Two Point-of-Care Prothrombin Time (PT) Monitoring Systems (CoaguChek Mini and TAS PT-NC) with Fresh Plasmas Based on Whole-Blood Equivalent PT

Discussion

Member takes

Implication

Structured PICO

Cite This Study

European Concerted Action on Anticoagulation. Evaluation of a Method for International Sensitivity Index Calibration of Two Point-of-Care Prothrombin Time (PT) Monitoring Systems (CoaguChek Mini and TAS PT-NC) with Fresh Plasmas Based on Whole-Blood Equivalent PT

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider