Why the study?
Does a simplified calibration method using fewer lyophilized plasma samples provide reliable ISI and INR for whole blood PT monitors compared to the standard 80-sample WHO guideline?
Population
Plasma samples from patients receiving coumarin, healthy subjects, and plasma samples artificially depleted…
Comparison
Simplified International Sensitivity Index… vs World Health Organization guidelines requiring…
Design
Other
Authors
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May simplify ISI calibration for point-of-care PT monitors but should not yet change practice; leaves open prospective validation against WHO standards.
Does a simplified calibration method using fewer lyophilized plasma samples provide reliable ISI and INR for whole blood PT monitors compared to the standard 80-sample WHO guideline?
ISI calibration of whole blood PT monitors can be simplified using significantly fewer lyophilized plasma samples than currently recommended by WHO guidelines.
Poller et al. (2003) studied this question.
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