Population
Mammalian cells and bacteria used for screening a library of bicistronic plasmids
Comparison
Fluorescent protein-based screen using a library… vs Encephalomyocarditis virus IRES element variant…
Design
Preclinical
Authors
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May enable IRES-targeted antiviral strategies; leaves open translation to cardiovascular models or therapies.
A novel fluorescent protein-based screen successfully identified small synthetic IRES elements that function in multiple cell types and can probe the mechanism of IRES-mediated translation.
Venkatesan et al. (2001) studied this question.
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