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January 1, 2004Journal of smooth muscle research Japanese sectionOpen Access

Endothelial dysfunction in diabetes is mediated by increased oxidized LDL, ET-1, oxidative stress, and decreased insulin/growth factor action, which can be improved by targeting these pathways.

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Population

Diabetic animal models (type 1 and type 2) and humans with diabetes

Design

Review

Authors

TKTsuneo KobayashiHoshi UniversityTMTakayuki MatsumotoUniversity of MiyazakiKKKatsuo KamataHoshi University

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Overview

Highlights potential targets for diabetic endothelial dysfunction; leaves open whether pathway-specific therapies improve outcomes.

Structured PICO

P
Population
Diabetic animal models (type 1 and type 2) and humans with diabetes

This review highlights the multifactorial mechanisms of endothelial dysfunction in diabetes and potential therapeutic targets to improve endothelium-dependent vasodilation.

Cite This Study

Kobayashi et al. (2004) studied this question.

synapsesocial.com/papers/6a7c2873edcd5d2e111f6c42https://doi.org/10.1540/heikatsukinzashi1997.8.j49
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial dysfunction in diabetes2000 · 1,168 citations
  2. 2Possible Involvement of Insulin and Oxidative Stress in Vascular Dysfunction of Diabetic Mellitus2008 · 9 citations
  3. 3Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications2019 · 36 citations
  4. 4Endothelial Dysfunction in Diabetes Mellitus2000 · 71 citations
  5. 5The Endothelium in Health and Disease-A Target for Therapeutic Intervention.2003 · 119 citations