Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 2008YAKUGAKU ZASSHIOpen Access

Hyperinsulinemia and hyperglycemia impair NO production and responsiveness in aortic strips, potentially via excessive peroxynitrite generation and decreased sarcoendoplasmic reticulum Ca(2+) ATPase function.

View Full Paper
Ask AI
Bookmark
Share

Population

Diabetic animal models (models of hyperinsulinemia and hyperglycemia)

Design

Review

Authors

TKTsuneo Kobayashi

Discussion

Loading...

Member takes

Overview

May implicate peroxynitrite in diabetic endothelial dysfunction; hypothesis-generating for therapies, needs clinical validation.

Structured PICO

P
Population
Diabetic animal models (models of hyperinsulinemia and hyperglycemia)
O
Outcome
Vascular dysfunction (impairment of endothelium-dependent relaxation)surrogate

Hyperinsulinemia and oxidative stress in diabetes may drive vascular dysfunction through peroxynitrite-mediated impairment of endothelium-dependent relaxation.

Cite This Study

Tsuneo Kobayashi (2008) studied this question.

synapsesocial.com/papers/6a758be04d6cec11745ffeb0https://doi.org/10.1248/yakushi.128.1013
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antioxidants, diabetes and endothelial dysfunction2000 · 272 citations
  2. 2ENDOTHELIAL DYSFUNCTION IN DIABETIC ANIMAL MODELS2004 · 2 citations
  3. 3Diabetes, Oxidative Stress and Endothelial Dysfunction2019 · 13 citations
  4. 4Endothelial Dysfunction in Diabetes – Clasic Sources of Vascular Oxidative Stress (Nadph Oxidases, Enos Uncoupling and Xanthine Oxidase)2013 · 1 citations
  5. 5Malfunction of Vascular Control in Lifestyle-Related Diseases: Mechanisms Underlying Endothelial Dysfunction in the Insulin-Resistant State2004 · 29 citations