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January 1, 2003Journal of Smooth Muscle ResearchOpen Access

Administration of tetrahydrobiopterin partially restores endothelial function in leptin-deficient mice with spontaneous type II diabetes and in human vascular tissue harvested for CABG.

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Population

Leptin-deficient mice with spontaneous type II diabetes and human vascular tissue harvested for coronary…

Design

Review

Authors

CTChris R. TriggleMHMorley D. HollenbergTATodd J. Anderson

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Overview

Hypothesis-generating for tetrahydrobiopterin in diabetic vasculopathy; should not yet change clinical practice.

Structured PICO

P
Population
Leptin-deficient mice (db/db) with spontaneous type II diabetes and human vascular tissue harvested for coronary artery bypass grafting (CABG)
I
Intervention
Tetrahydrobiopterin administration
O
Outcome
Endothelial functionsurrogate

Tetrahydrobiopterin availability plays an important role in vascular dysfunction associated with Type II diabetes, and its administration can partially restore endothelial function.

Cite This Study

Triggle et al. (2003) studied this question.

synapsesocial.com/papers/6a8bb992f71b672e3df490eahttps://doi.org/10.1540/jsmr.39.249
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial dysfunction in diabetes2000 · 1,168 citations
  2. 2ENDOTHELIAL DYSFUNCTION IN DIABETIC ANIMAL MODELS2004 · 2 citations
  3. 3Endothelial nitric oxide and cardiovascular disease1994 · 110 citations
  4. 4Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update2011 · 88 citations
  5. 5Microvessel haemodynamics: interesting news which is not NO news?2003