Key result
EDHF rather than nitric oxide primarily mediates abnormal microvessel vasorelaxation in obese patients.
Why the study?
The mechanisms linking metabolic and vascular consequences of visceral obesity and type 2 diabetes, particularly the role of endothelial factors in microvessel vasodilation, remain incompletely understood.
Comparison
EDHF-dependent versus NO-dependent vasodilation in microvessels of obese subjects with insulin resistance
Design
Editorial discussing recent research findings
Authors
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EDHF may contribute to microvascular dysfunction in obesity; hypothesis-generating and should not yet change practice.
Highlights the potential role of EDHF-dependent vasodilation in microvascular dysfunction and metabolic/hemodynamic coupling in obesity and insulin resistance.
Eelco J.P. de Koning (2003) conducted an editorial in Obesity and insulin resistance. In a discussed study of 10 obese subjects, endothelium-derived hyperpolarizing factor (EDHF), rather than nitric oxide, was primarily involved in abnormal microvessel vasorelaxation.
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