Key result
In healthy individuals, insulin infusion did not alter flow-mediated dilatation, but co-infusion with clonidine increased vascular responses to glyceryltrinitrate by 45%.
Why the study?
Does insulin infusion affect endothelium-independent and endothelium-dependent vasodilation in healthy individuals, and is this mediated by sympathetic activation?
Population
Healthy individuals (n=5 per group in the discussed study by Morgantini et al.)
Comparison
Insulin infusion with euglycemic clamp, with or… vs Control
Design
Editorial
Authors
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Should not alter vascular testing in practice; hypothesis-generating for sympathetic mediation of insulin effects in health.
Does insulin infusion affect endothelium-independent and endothelium-dependent vasodilation in healthy individuals, and is this mediated by sympathetic activation?
This editorial highlights evidence that in healthy individuals, insulin-induced decreases in endothelium-independent vascular relaxations may be mediated by sympathetic activation.
Aggarwal et al. (2012) conducted an editorial in Healthy individuals (n=5). Insulin infusion vs. Control was evaluated on Flow-mediated dilatation and vasodilatatory responses to sublingual glyceryl trinitrate. In healthy individuals, insulin infusion did not alter flow-mediated dilatation, but co-infusion with clonidine increased vascular responses to glyceryltrinitrate by 45%.
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