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To investigate the significance of Her-2 transformation in breast cancer after treatment.A case of breast cancer with lung metastasis was reported.The second biopsy showed Her2 transformation, and anti Her2 treatment was performed and the literature was reviewed.Before treatment, the primary lesion of the patient was Luminal B type, Her2 was negative, and after comprehensive treatment, the needle biopsy of pulmonary metastatic lesions was Her2 positive.Her2 status of patients with breast cancer may change after comprehensive treatment, and re biopsy can be considered to provide more treatment opportunities for patients.
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