Key result
Tempol significantly attenuated cardiac hypertrophy and prevented the decrease in left ventricular area of fractional shortening (from 22% to 33%) in fructose-fed mice subjected to transverse aortic constriction.
Why the study?
Does tempol attenuate pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet?
Population
Mice subjected to transverse aortic constriction or sham surgery, fed a high-fructose diet or high-starch diet
Comparison
Tempol [0.1% (wt/wt) in the chow] for 8 weeks vs High-fructose or high-starch diet without tempol
Design
Preclinical
Follow-up
8 weeks
Authors
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May support antioxidant testing in metabolic-pressure overload models; leaves open translation to human disease.
Does tempol attenuate pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet?
Absolute Event Rate: 33% vs 22%
p-value: p=<0.05
The antioxidant tempol attenuates cardiac hypertrophy, LV remodeling, and contractile dysfunction in a mouse model of pressure overload exacerbated by a high-fructose diet.
Chess et al. (2008) studied Pressure overload-induced cardiac hypertrophy and contractile dysfunction. Tempol vs. No tempol was evaluated on Left ventricular area of fractional shortening (aFS) in fructose-fed TAC mice (p=<0.05). Tempol significantly attenuated cardiac hypertrophy and prevented the decrease in left ventricular area of fractional shortening (from 22% to 33%) in fructose-fed mice subjected to transverse aortic constriction.
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