Why the study?
Does dietary carbohydrate composition (high starch vs high fructose) affect cardiac remodeling and mortality in a mouse model of pressure overload?
Population
Male C57BL/6J mice of 6 wk of age undergoing transverse aortic constriction or sham surgery
Comparison
High-starch chow or high-fructose chow for 16… vs Standard chow
Design
Preclinical
Follow-up
16 weeks
Authors
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High-fructose diets may worsen pressure-overload mortality in mice; hypothesis-generating for carbohydrate effects on human HF.
Does dietary carbohydrate composition (high starch vs high fructose) affect cardiac remodeling and mortality in a mouse model of pressure overload?
In a mouse model of pressure overload, a high-fructose diet exacerbated cardiac dysfunction and mortality, whereas a high-starch diet was protective against adverse remodeling.
Chess et al. (2007) studied this question.
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