Key result
Exogenous ketone therapy represents a promising new therapeutic approach to increase cardiac efficiency, reduce energy deficit, and improve cardiac function in patients with heart failure.
Why the study?
Heart failure morbidity and mortality remain high despite existing treatments, prompting the evaluation of exogenous ketones as a potential approach to improve cardiac energetics and function.
Does exogenous ketone therapy improve cardiac function and energy metabolism in patients with heart failure?
Does exogenous ketone therapy improve cardiac function and energy metabolism in patients with heart failure?
Exogenous ketone therapy is a promising metabolic intervention to address myocardial energy starvation in heart failure, though its long-term clinical benefits remain to be proven.
Hypothesis-generating for HF; RCTs needed before any practice change.
Heart failure is of major clinical and economic importance and remains a major public health problem worldwide. Despite existing treatment approaches, morbidity and mortality in these patients remains high. The progression of heart failure is accompanied by an increase in the metabolism of ketone bodies. The use of exogenous ketones may become a new therapeutic approach to increase cardiac efficiency, reduce energy deficit and improve cardiac function in patients with heart failure. The review presents the available data on ketone body metabolism in patients with heart failure, preclinical and clinical studies demonstrating the beneficial effects of exogenous ketone therapy in animal models and human studies with heart failure, and describes the potential pros and cons of using this therapeutic approach.
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Aksenova et al. (2023) conducted a review in Heart failure. Exogenous ketones was evaluated. Exogenous ketone therapy represents a promising new therapeutic approach to increase cardiac efficiency, reduce energy deficit, and improve cardiac function in patients with heart failure.
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