Key result
Therapeutic ketosis holds significant promise as a potential treatment paradigm for heart failure, particularly in patients with reduced ejection fraction.
Why the study?
Despite existing therapies, patients with HF experience substantial morbidity and mortality, highlighting an urgent need for novel pathophysiological mechanisms and therapies beyond traditional neurohormonal and hemodynamic targets.
Does therapeutic ketosis or ketone metabolic modulation provide clinical benefit in patients with heart failure?
Does therapeutic ketosis or ketone metabolic modulation provide clinical benefit in patients with heart failure?
Therapeutic ketosis represents a promising novel pathophysiological and therapeutic target for the management of heart failure.
No takes yet. Share an insight, caveat, or question.
Should not change HFrEF practice yet; leaves open a metabolic target for future RCTs.
Selvaraj et al. (2020) conducted a review in Heart failure. Therapeutic ketosis was evaluated. Therapeutic ketosis holds significant promise as a potential treatment paradigm for heart failure, particularly in patients with reduced ejection fraction.
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