Key result
Multiple Endo-PAT measurements within the same day significantly increased the reactive hyperemia index by 30.1% at 4 hours compared to baseline, demonstrating poor intraday repeatability.
Why the study?
Does the timing of Endo-PAT measurements affect the repeatability of Reactive Hyperemia Index (RHI) in healthy volunteers?
Observational (n=47)
No
Does the timing of Endo-PAT measurements affect the repeatability of Reactive Hyperemia Index (RHI) in healthy volunteers?
Answers are grounded in this paper and cite their sources.
Endo-PAT measurements of RHI show good interday but poor intraday repeatability, highlighting the need to standardize protocols and avoid multiple same-day measurements.
OBJECTIVE: This study aimed to investigate the inter-and intraday repeatability of RHI measured by Endo-PAT in healthy volunteers. METHODS: Interday RHI repeatability was tested in two consecutive days in a group of 31 male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 hour in a group of 16 volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, CV, CR, and ICC were measured. RESULTS: While interday RHI repeatability was found to be reliable (CV: 6.0%; CR: 0.51; ICC: 0.77), multiple evaluations within the same day significantly (P<.001) affected RHI (repeatability of the measurement -CV: 18.8%; CR: 1.26; ICC: 0.48). In particular, a significant increase in RHI occurred at 4 hour compared to 2 hour (+16.8%; P<.05) and to baseline (+30.1%; P<.05). CONCLUSIONS: RHI showed good interday but poor intraday repeatability. Multiple evaluations increased RHI especially in subjects with endothelial dysfunction who improved or reversed their impairment. These results show the potential limitations of multiple Endo-PAT measurements within the same day and the importance of standardizing the protocols before RHI evaluations.
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Bo’ et al. (2016) conducted an observational in Healthy (n=47). Multiple intraday Endo-PAT measurements vs. Baseline measurement was evaluated on Intraday repeatability of reactive hyperemia index (RHI) (p=<0.001). Multiple Endo-PAT measurements within the same day significantly increased the reactive hyperemia index by 30.1% at 4 hours compared to baseline, demonstrating poor intraday repeatability.
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