Key result
During dobutamine stress, individuals with myocardial ischaemia exhibited a significant increase in sympathetic modulation (LFnu 56% vs 40%, P<0.05) compared to non-ischaemic responders.
Why the study?
Does dobutamine stress induce different autonomic responses in individuals with myocardial ischaemia compared to those without?
Population
314 individuals undergoing dobutamine stress echocardiography to detect or exclude myocardial ischaemia
Comparison
Dobutamine stress in patients with myocardial… vs Dobutamine stress in patients without myocardial…
Design
Cross-sectional
Authors
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Autonomic differences during dobutamine stress may aid ischaemia detection; hypothesis-generating and should not yet change practice.
Observational (n=314)
Does dobutamine stress induce different autonomic responses in individuals with myocardial ischaemia compared to those without?
Absolute Event Rate: 56% vs 40%
p-value: p=< 0.05
Dobutamine stress induces a sympathetic predominance in patients with myocardial ischaemia, contrasting with a parasympathetic predominance in non-ischaemic patients, with the sympathetic response scaling with ischaemic burden.
Sharma et al. (2015) conducted an observational in Myocardial ischaemia (n=314). Myocardial ischaemia vs. Absence of myocardial ischaemia was evaluated on Low-frequency normalised units (LFnu) at peak stress (p=< 0.05). During dobutamine stress, individuals with myocardial ischaemia exhibited a significant increase in sympathetic modulation (LFnu 56% vs 40%, P<0.05) compared to non-ischaemic responders.
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