What question did this study set out to answer?

To determine whether angiotensin II and the AT2 receptor-selective agonist CGP 42112 regulate T-type calcium currents in non-differentiated NG108-15 cells.

September 7, 1992FEBS LettersOpen Access

The angiotensin AT2 receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells

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Population

Non-differentiated NG108-15 cells expressing only AT2 receptors

Design

Preclinical

Authors

BBBruno BuissonBiogen (United States)SBSerge P. BottariCentre National de la Recherche Scientifique MGMarc de GasparoGeneral / Preventive / Lipids

Discussion

Member takes

Implication

No immediate clinical implications from NG108-15 data; leaves open AT2 modulation of T-type currents in vivo.

Key Points

To determine whether angiotensin II and the AT2 receptor-selective agonist CGP 42112 regulate T-type calcium currents in non-differentiated NG108-15 cells.
Measured calcium currents in non-differentiated NG108-15 cells that exclusively express AT2 receptors.
Administered angiotensin II and the selective ligand CGP 42112 while assessing current changes across various membrane potentials.
Angiotensin II and CGP 42112 decreased the T-type calcium current at membrane potentials exceeding -40 mV.
Ligand application shifted the current-voltage relationship at lower potentials, with peak inhibitory responses occurring between 5 and 10 minutes.

Structured PICO

Population

Non-differentiated NG108-15 cells expressing only AT2 receptors

Intervention

Angiotensin II (AII) and AT2 receptor-selective ligand CGP 42112

Outcome

T-type calcium current modulationsurrogate

Angiotensin II modulates T-type calcium currents via the AT2 receptor in NG108-15 cells, suggesting a mechanism for its neurophysiological actions.

Cite This Study

Buisson et al. (1992) studied this question.

synapsesocial.com/papers/6a7c83034ece96453776de64 https://doi.org/10.1016/0014-5793(92)81086-2

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The angiotensin AT2 receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The angiotensin AT2 receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider