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January 1, 1995Journal of Biological ChemistryOpen Access

A G Protein Is Involved in the Angiotensin AT2 Receptor Inhibition of the T-Type Calcium Current in Non-differentiated NG108-15 Cells

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Population

Non-differentiated NG108-15 cells

Design

Preclinical

Authors

BBBruno BuissonBiogen (United States)LLLiette LaflammeUniversité de SherbrookeSBSerge P. BottariCentre National de la Recherche Scientifique

Discussion

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Implication

Does not support changes in cardiovascular therapy; leaves open AT2-mediated T-type current modulation in neuronal models.

Structured PICO

P
Population
Non-differentiated NG108-15 cells
I
Intervention
Angiotensin II (100 nM) and CGP 42112 (100 nM)
O
Outcome
T-type calcium current amplitudesurrogate

Angiotensin II modulates membrane conductance through the AT2 receptor via a mechanism involving phosphotyrosine phosphatase and a G protein in NG108-15 cells.

Cite This Study

Buisson et al. (1995) studied this question.

synapsesocial.com/papers/6a701eda31a3df824328660dhttps://doi.org/10.1074/jbc.270.4.1670
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-II Receptor Subtypes in Fetal Tissues of the Rat: Autoradiography, Guanine Nucleotide Sensitivity, and Association with Phosphoinositide Hydrolysis1991 · 149 citations
  2. 2Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.1993 · 716 citations
  3. 3Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.1991 · 245 citations
  4. 4Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells1988 · 59 citations
  5. 5Characterization of brain angiotensin II AT2 receptor subtype using [125I] CGP 42112A1993 · 25 citations