Why the study?
Does premature stimulation affect the kinetics and magnitude of HERG K+ channel currents in transfected CHO cells?
Population
Chinese hamster ovary (CHO) cells transfected with human ether-à-go-go-related gene (HERG) K(+) channels
Comparison
Premature stimulation using action potential… vs Normally paced action potential waveforms
Design
Preclinical
Authors
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Informs HERG kinetic models for premature beats; leaves open translation to human arrhythmia suppression.
Does premature stimulation affect the kinetics and magnitude of HERG K+ channel currents in transfected CHO cells?
The specific kinetic responses of HERG K+ channels to premature stimulation suggest they play a role in suppressing arrhythmias initiated by early afterdepolarizations and premature beats.
Martyn et al. (2001) studied this question.
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