Key result
The rat model of heterotopic heart transplantation provides a reproducible and valuable tool for studying organ preservation, immunology, and replacement of the failing heart.
Why the study?
The review aimed to describe and discuss the rat animal model of heart transplantation, an underestimated method for researching prevention, monitoring, and treatment of graft responses.
The modified rat model of heterotopic heart transplantation provides a reproducible and valuable preclinical tool for studying organ preservation, rejection mechanisms, and sex differences in transplantology.
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Supports preclinical cardiac research on preservation and immunology; leaves open translation to clinical transplantation.
Śliwka et al. (2020) conducted a review in Heart transplantation. Heterotopic heart transplantation model was evaluated. The rat model of heterotopic heart transplantation provides a reproducible and valuable tool for studying organ preservation, immunology, and replacement of the failing heart.
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