Key result
Higher visit-to-visit systolic blood pressure variability increased the risk of cardiovascular events, particularly in normal-weight individuals (highest quartile HR 2.20; 95% CI 1.46-3.31).
Why the study?
This study was performed to explore the effects of visit-to-visit blood pressure variability on cardiovascular events in people with various body mass indexes.
Does high visit-to-visit blood pressure variability increase the risk of cardiovascular events in populations with different body mass indexes?
Cohort (n=41,043)
Does high visit-to-visit blood pressure variability increase the risk of cardiovascular events in populations with different body mass indexes?
Hazard Ratio: 2.2 (95% CI 1.46–3.31)
Higher visit-to-visit systolic blood pressure variability is associated with an increased risk of cardiovascular events, particularly in normal-weight individuals.
May support risk stratification by BP variability in normal-weight patients; leaves open whether reducing variability improves outcomes.
Objective This study was performed to explore the effects of visit-to-visit blood pressure variability (BPV) on cardiovascular events (CVEs) in people with various body mass indexes (BMIs). Design Prospective cohort study. Setting The average real variability of systolic blood pressure (ARV SBP ) was the indicator for visit-to-visit BPV. The participants were divided into three groups: normal weight, overweight and obesity. We further divided these groups into four subgroups based on the ARV SBP . A Cox regression model was used to calculate the HRs of the ARV SBP on CVEs in the same and different BMI groups. Additionally, a competitive risk model was used to calculate the HRs of the ARV SBP on CVEs in the same BMI group. Participants In total, 41 043 individuals met the inclusion criteria (no historical CVEs or tumours, no incidence of CVEs or tumours and no death during the four examinations) and had complete systolic blood pressure and BMI data. Results A total of 868 CVEs occurred. The cumulative incidence of CVEs increased as ARV SBP rose in both the normal weight and overweight groups. In same BMI groups, the risk of CVEs significantly increased as ARV SBP increased only in the normal weight group (highest quartiles of ARV SBP : HR (95% CI) 2.20 (1.46–3.31)). In the different BMI groups, the risk of CVEs in the ARV SBP subgroup in each BMI group was higher than that the least quintile of ARV SBP in the normal weight group (highest quartiles of ARV SBP in obesity: HR (95% CI) 2.28 (1.47–3.55)). The result of the competitive risk model did not change. Conclusions As BMI and ARV SBP increase, the risk of CVEs increases. However, the risk of visit-to-visit BPV on CVEs varies in different BMI groups, especially in people of normal weight. Trial registration number CHiCTR-TNC1100 1489.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2020) conducted a cohort in Cardiovascular events (n=41,043). Visit-to-visit systolic blood pressure variability (ARV SBP) vs. Lower visit-to-visit systolic blood pressure variability was evaluated on Cardiovascular events (CVEs) (HR 2.20, 95% CI 1.46-3.31). Higher visit-to-visit systolic blood pressure variability increased the risk of cardiovascular events, particularly in normal-weight individuals (highest quartile HR 2.20; 95% CI 1.46-3.31).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: