Key result
The highest versus lowest quartile of systolic blood pressure variability was associated with an increased risk of all-cause mortality (HR 1.37; 95% CI 1.19-1.57) and cardiovascular disease.
Why the study?
Does higher visit-to-visit blood pressure variability increase the risk of all-cause mortality and cardiovascular events in the general population?
Cohort (n=52,387)
Does higher visit-to-visit blood pressure variability increase the risk of all-cause mortality and cardiovascular events in the general population?
Hazard Ratio: 1.37 (95% CI 1.19–1.57)
Higher visit-to-visit blood pressure variability is independently associated with increased risks of all-cause mortality and cardiovascular events in the general population.
Higher visit-to-visit SBP variability signals mortality risk in observational data; extends associations but leaves causal benefit of targeting it open.
The association between blood pressure variability (BPV) and the risk of all-cause mortality and cardiovascular diseases (CVD) is not well understood. The Kailuan study is a prospective longitudinal cohort study on cerebrovascular events and cardiovascular factors. In this study, resting blood pressure was measured at baseline and every 2 years from 2006 to 2007. BPV is mainly defined as the coefficient of variation (CV). Hazard ratio (HR), with 95% confidence intervals (CI) was calculated using Cox regression model. Among 52 387 participants, we identified 1817 who ended up with all-cause death and 1198 with CVD. Each 4.68% increase in BPV was associated with a 13% increase in the risk of mortality (HR = 1.13, 95% CI = 1.09-1.18) and a 7% increase in CVD (HR = 1.07, 95% CI = 1.02-1.13), respectively. After adjustment of confounding factors, the HR of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.37 (1.19, 1.57) for all-cause death, 1.18 (1.01, 1.39) for CVD. Similar results were also observed when BPV was measured by different parameters. We concluded that visit-to-visit BPV was associated with all-cause death and cardiovascular and cerebrovascular events in Chinese general population.
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Dai et al. (2018) conducted a cohort in General population (n=52,387). Visit-to-visit blood pressure variability vs. Lowest quartile of blood pressure variability was evaluated on All-cause mortality (HR 1.37, 95% CI 1.19-1.57). The highest versus lowest quartile of systolic blood pressure variability was associated with an increased risk of all-cause mortality (HR 1.37; 95% CI 1.19-1.57) and cardiovascular disease.
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