Key result
Visit-to-visit variability of clinic systolic blood pressure independently predicted All CVD events (HR 2.20; 95% CI 1.25-3.88; P<0.01), whereas sleep SBP variability predicted Hard CVD events.
Why the study?
Does visit-to-visit and ambulatory blood pressure variability predict incident cardiovascular events in patients with hypertension?
Population
457 hypertensive patients, mean age 67.0 ± 9.2 years
Design
Cohort
Follow-up
67 ± 26 months
Authors
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BP variability may refine CVD risk stratification in hypertension; extends observational data but leaves causal effects and practice change open.
Cohort (n=457)
Does visit-to-visit and ambulatory blood pressure variability predict incident cardiovascular events in patients with hypertension?
Hazard Ratio: 2.2 (95% CI 1.25–3.88)
p-value: p=<0.01
Visit-to-visit clinic BPV and ambulatory sleep BPV are distinct and useful predictors of different types of cardiovascular outcomes in hypertensive patients.
Hoshide et al. (2012) conducted a cohort in Hypertension (n=457). Blood pressure variability (clinic and ambulatory) was evaluated on All CVD events (HR 2.20, 95% CI 1.25-3.88, p=<0.01). Visit-to-visit variability of clinic systolic blood pressure independently predicted All CVD events (HR 2.20; 95% CI 1.25-3.88; P<0.01), whereas sleep SBP variability predicted Hard CVD events.
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