Key result
High visit-to-visit systolic blood pressure variability (highest vs. lowest quartile) significantly increased the risk of any stroke (HR 1.44) and hemorrhagic stroke (HR 2.17) in the general population.
Why the study?
Does higher visit-to-visit blood pressure variability increase the risk of stroke in a general population cohort?
Population
57,927 participants from southeast of Beijing who completed 3 health examinations between 2006 and 2010
Comparison
Highest quartile of visit-to-visit systolic… vs Lowest quartile of visit-to-visit systolic blood…
Design
Cohort
Follow-up
median 3.0 years
Authors
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Higher BP variability was associated with stroke risk; leaves open whether targeting it reduces incidence in primary prevention.
Cohort (n=54,650)
Yes
Does higher visit-to-visit blood pressure variability increase the risk of stroke in a general population cohort?
Hazard Ratio: 1.44 (95% CI 1.11–1.87)
Absolute Event Rate: 1.48% vs 0.86%
p-value: p=<0.05
Higher visit-to-visit blood pressure variability is independently associated with an increased risk of first stroke, particularly hemorrhagic stroke, suggesting it may be an important therapeutic target.
Dai et al. (2017) conducted a cohort in General population (n=54,650). High visit-to-visit systolic blood pressure variability (highest quartile of CV) vs. Low visit-to-visit systolic blood pressure variability (lowest quartile of CV) was evaluated on First stroke (any stroke) (HR 1.44, 95% CI 1.11, 1.87, p=<0.05). High visit-to-visit systolic blood pressure variability (highest vs. lowest quartile) significantly increased the risk of any stroke (HR 1.44) and hemorrhagic stroke (HR 2.17) in the general population.
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