Key result
True resistant hypertension significantly increased the risk of total cardiovascular events compared to controlled nonresistant hypertension (HR 1.66; 95% CI 1.12-2.48; P=0.012).
Why the study?
Resistant hypertension is an important cardiovascular risk factor, but the specific impact of uncontrolled resistant hypertension diagnosed via ambulatory blood pressure monitoring on heart failure and cardiovascular events required investigation.
Does true resistant hypertension diagnosed by ambulatory blood pressure monitoring increase the risk of cardiovascular events and heart failure compared to nonresistant hypertension in patients without prior heart failure?
Population
JAMP study patients with hypertension and no history of HF
Comparison
True resistant vs pseudoresistant vs well-controlled nonresistant vs uncontrolled nonresistant hypertension
Design
Prospective cohort study analysis
Follow-up
4.5±2.4 years
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True resistant hypertension on ABPM signals higher HF risk; leaves open whether ABPM-guided therapy improves outcomes.
Cohort
Does true resistant hypertension diagnosed by ambulatory blood pressure monitoring increase the risk of cardiovascular events and heart failure compared to nonresistant hypertension in patients without prior heart failure?
Hazard Ratio: 1.66 (95% CI 1.12–2.48)
p-value: p=0.012
True resistant hypertension diagnosed by 24-hour ambulatory blood pressure monitoring is a significant independent risk factor for cardiovascular events, particularly heart failure.
A 2021 study conducted a cohort in Hypertension. True resistant hypertension vs. Controlled nonresistant hypertension was evaluated on Total cardiovascular events, including atherosclerotic cardiovascular disease and heart failure (HR 1.66, 95% CI 1.12-2.48, p=0.012). True resistant hypertension significantly increased the risk of total cardiovascular events compared to controlled nonresistant hypertension (HR 1.66; 95% CI 1.12-2.48; P=0.012).
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