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August 1, 2000HypertensionOpen Access

Endothelial function was significantly more impaired in patients with diabetes (4.7+/-1.8%) and impaired glucose tolerance (6.3+/-2.9%) compared to normal glucose tolerance (8.4+/-4.5%) (P<0.05).

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Why the study?

Is abnormal glucose tolerance more closely associated with endothelial dysfunction than left ventricular hypertrophy in unmedicated hypertensive patients?

Population

107 unmedicated hypertensive patients (mean age 54+/-10 years) with fasting blood glucose <7.0 mmol/L

Comparison

Abnormal glucose tolerance vs Normal glucose tolerance

Design

Cross-sectional

Authors

HTHirofumi TomiyamaYKYutaka KimuraRORyo Okazaki

Discussion

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Overview

Abnormal glucose tolerance was associated with endothelial dysfunction in unmedicated hypertension; hypothesis-generating versus LVH and needs prospective confirmation.

Structured PICO

Is abnormal glucose tolerance more closely associated with endothelial dysfunction than left ventricular hypertrophy in unmedicated hypertensive patients?

P
Population
107 unmedicated hypertensive patients (mean age 54+/-10 years) with fasting blood glucose <7.0 mmol/L
I
Intervention
Abnormal glucose tolerance (assessed by 75-g oral glucose tolerance test)
C
Comparator
Normal glucose tolerance
O
Outcome
Endothelial function assessed by change in brachial artery diameter in response to reactive hyperemiasurrogate

Abnormal glucose tolerance, rather than left ventricular hypertrophy, is closely associated with endothelial dysfunction in unmedicated hypertensive patients.

Cite This Study

Tomiyama et al. (2000) studied this question.

synapsesocial.com/papers/6a7ca2f580d29ce2cbfab3d4https://doi.org/10.1161/01.hyp.36.2.245
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular hypertrophy and preclinical impaired glucose tolerance and diabetes mellitus contribute to abnormal left ventricular diastolic function in hypertensive patients2005 · 9 citations
  2. 2One-Hour Postload Plasma Glucose Levels and Left Ventricular Mass in Hypertensive Patients2011 · 92 citations
  3. 3Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension.2002 · 30 citations
  4. 4Role of glucose intolerance in cardiac diastolic function in essential hypertension.1994 · 37 citations
  5. 5Left ventricular hypertrophy is associated with a stronger impairment of non‐oxidative glucose metabolism in hypertensive patients1995 · 32 citations